CATEGORY: NANOPARTICLES
J. Serb. Chem. Soc. 78 (4) 463–468 (2013)
A
novel approach to bis(indolyl)methanes using nickel nanoparticles as a reusable
catalyst under solvent-free conditions
Abolfazl Olyaei (1)*, Mohsen Vaziri (1), Reza Razeghi (1), Bahareh
Shams (1) And Hasan Bagheri (2)
1 Department of Chemistry, Payame Noor University, P. O. Box 19395–3697,
Tehran, Iran and
2 Department of Chemistry, Takestan Branch, Islamic Azad University, Takestan,
Iran
Abstract:
Nano-sized
nickel as a catalyst has been developed for the electrophilic substitution
reactions of indole with various aromatic aldehydes under solvent-free
conditions to afford the corresponding bis(indolyl)methanes in high to
excellent yields. The described method has promising features, such as no
hazardous organic solvents or catalysts, short reaction time, high product
yields, simple work-up procedure, reusable catalyst and easy product separation
without further purification with column chromatography.
Introduction
The efficiency of heterogeneous catalysis in organic synthesis can be improved
by employing nano-sized catalysts because of their extremely small size and
large surface to volume ratio. It was recently demonstrated that Ni
nanoparticles as catalysts offer great opportunities for a wide range of
applications in organic synthesis and chemical manufacturing processes,
including the chemoselective oxidative coupling of thiols,1 reduction of
aldehydes and ketones,2–4 hydrogenation of olefins5 and supports for hydrogen
adsorption.6 Thus, the remarkable catalytic activity and easy synthesis,
simplicity and reusability of Ni nanoparticles encouraged the present
utilization of them as a catalyst for the synthesis of bis(indolyl)methanes
(BIM).
Free Full Text Source: http://www.doiserbia.nb.rs/img/doi/0352-5139/2013/0352-51391200076O.pdf
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