Steroid-Derived Naphthoquinoline Asphaltene Model Compounds: Hydriodic Acid Is the Active Catalyst in I2-Promoted Multicomponent Cyclocondensation Reactions

Steroid-Derived Naphthoquinoline Asphaltene Model Compounds: Hydriodic Acid Is the Active Catalyst in I2-Promoted Multicomponent Cyclocondensation Reactions

Type	Journal Article
Author	Matthias Schulze
Author	David E. Scott
Author	Safat, Kuwait Petroleum Research Center, Kuwait Institute for Scientific Research
URL	http://dx.doi.org/10.1021/acs.orglett.5b03193
Volume	17
Issue	23
Pages	5930-5933
Publication	Organic Letters
Date	December 4, 2015
Abstract	Researchers employed a multicomponent cyclocondensation reaction between 2-aminoanthracene, aromatic aldehydes, and 5-α-cholestan-3-one to synthesize model asphaltene compounds. They identified the active catalyst for this reaction as hydriodic acid, which is formed in situ from the reaction of iodine with water, while iodine is not a catalyst under anhydrous conditions.